Since the series is notorious for it's voice acting and dialogue that is unintentionally funny.

My faves:
"What is this?" then followed by Wesker saying "Wow, what a mansion!" on RE original.
"That was too close, you were almost a Jill sandwich"-RE original.
"You want STARS, i'll give you stars"-RE 3.
"You got a smoke?" and "I got gum"-RE 4.
"It might be handy if you, the master of unlocking take it with you"-RE original.